Sertoli Cells

Definition - What does Sertoli Cells mean?

Sertoli cells are cells in the testes that play a supporting role in the development of sperm cells. Sertoli cells are located within the seminiferous tubules where they act as a blood-testis barrier and provide nourishment for the developing spermatozoa (immature sperm). The number of Sertoli cells determines testicular size and spermatozoa output. Sertoli cells also play a role in male sexual development.

FertilitySmarts explains Sertoli Cells

Sertoli cells interpret signals from testosterone and follicle-stimulating hormone (FSH) to help facilitate the maturation of germs cells into spermatozoa. Spermatogenesis or the process of creating sperm, is regulated by a complex intermingling of hormones. Steroli cells are the only cells within the seminiferous tubules that have receptors for the hormones testosterone and FSH. Because of this, they play a crucial role as major targets of hormonal signals that regulate the process of sperm development.

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