Myo-inositol (MI)

Definition - What does Myo-inositol (MI) mean?

Myo-inositol (MYO) is a cellular building block produced naturally in the body that helps with signaling of some processes including insulin action, lipid metabolism, and cell growth, as well as acts at an antioxidant. Some diseases such as polycystic ovary syndrome (PCOS) lead to low levels of natural myo-inositol. Supplementation has been shown to improve the balance of hormones in PCOS as well as shown promise for fertility treatment.

In addition, myo-inositol may play a role in the process of cellular division, egg maturation, and fertilization. It has been proposed that myo-inositol supplementation can improve the quality of eggs and improve fertility outcomes during in vitro fertilization (IVF) treatment.

MYO is also known by its other forms called inositol, cyclohexitol, or inositol hexaphosphate (IP6).

FertilitySmarts explains Myo-inositol (MI)

Women with PCOS have had success in reducing side effects of their disease and normalizing their blood sugar levels with the use of myo-inositol. A study of myo-inositol treatment in combination with oral contraceptive pills (OCP) in teenagers with PCOS showed to reduce weight, balance hormones, and improve metabolic processes including blood sugar compare to the use of OCPs alone. They also found improvement and regularization of menstrual cycles occured. Another study used myo-inositol in combination with alpha lipoic acid in overweight women with PCOS. This combination proved to be effective in not only improving insulin resistance but also improved gonadotropin release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These are important hormones play an important role in normal fertility.

Studies of using MYO in women prior to hormonal stimulation during IVF have shown to increase egg quality and reduce the amount of FSH required during their cycles. Another small study of women who had experienced failed rounds of IVF were treated with MYO. In these women, there was an increased number of eggs and an improvement of response to hormonal stimulation. There was no difference in fertilization rate, implantation rate, and pregnancy.

MYO may be used in combination with other treatments to help women with PCOS in balancing hormones and aiding in their fertility. In otherwise healthy women, the use of MYO in IVF may need more data to support its use even though it has demonstrated potential benefits in egg quality.

MYO is taken orally as a supplement daily. It is also found in the diet from fruits, beans, grains, and nuts.

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