Definition - What does Blastocentesis mean?

A blastocentesis is a procedure where fluid from a 5-day embryo called a blastocyst is withdrawn and analyzed for the presence of any chromosomal abnormality. This procedure may offer an alternative source of DNA for preimplantation genetic screening (PGS) that is less invasive than removing trophectoderm cells (TE). The aim the tests is to evaluate the genetic health of the embryos produced during in vitro fertilization (IVF), to avoid the risk of transferring abnormal embryos. The procedure, is, however, still in the experimental stages.

FertilitySmarts explains Blastocentesis

An embryo at the blastocyst stage represents the most reliable stage for performing PGS or blastocentesis because the fluid within the blastocyst contains cell-free DNA. This DNA can be aspirated (withdrawn) while paying careful attention not to contaminate the fluid with any cellular material. The extracted DNA can then be considered as a true reflection of the blastocyst fluid content. Experts report that blastocentesis is a less invasive method to determine the chromosomal status of an embryo and may be the preferred option for PGS.

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