Granulocyte Colony Stimulating Factor (G-CSF)

Definition - What does Granulocyte Colony Stimulating Factor (G-CSF) mean?

Granulocyte colony stimulating factor (G-CSF) is a protein that stimulates the growth, division, and maturity of cells primarily in the bone marrow but it also has an action on cells in a maturing follicle, placenta, and the fetus and therefore plays an important role in female reproductive function. Repeated pregnancy losses due to the presence of a thin endometrium or due to impaired interactions between the fetus and the uterus are some of the known causes of infertility that poses a significant challenge in terms of treatment. G-CSF is a potential treatment for these conditions that is still in the experimental stage.

FertilitySmarts explains Granulocyte Colony Stimulating Factor (G-CSF)

During the early phases of implantation, the cells in the developing fetus and placenta start producing G-CSF that facilitates proper fetal and placental development and interaction with the uterus. Abnormalities in the production or response to G-CSF can lead to repeated miscarriages. When G-CSF is given as injections it has been shown to help these women have a successful pregnancy.

Women whose endometrium, the inner lining of the uterus, is thinner than 7 millimeters face difficulty in conceiving because it can interfere with the process of implantation. A thin endometrium also affects the success rates of assisted reproductive techniques like in vitro fertilization (IVF). G-CSF, when injected into the uterus, has been shown to improve the endometrial thickness and aid natural and assisted conception.

Luteinized unruptured follicle syndrome (LUFS) is a condition where there is a defect in the release of the matured egg from the ovary which commonly happens with the use of ovulation inducers that promote maturation of eggs. G-CSF has shown to be effective in preventing LUFS during ovulation induction.

G-CSF has shown promising results in both animal and human studies, but there are still controversies with regard to the use of G-CSF in repeated miscarriages and IVF failure. There is still no consensus on who would benefit the most from treatment with G-CSF and the exact methods of using it. With more data emerging from newer research, G-CSF is likely to be a groundbreaking treatment option for infertility.

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