Clomid Resistant

Definition - What does Clomid Resistant mean?

Clomid Resistant is a term used to describe women who do not show a favorable response to the drug Clomid, that is used to stimulate ovulation. Clomid resistance poses a challenge to couples who seeking treatment for infertility due to abnormalities of ovulation, and it may also indicate an underlying condition such as polycystic ovary syndrome (PCOS) or increased prolactin levels in the blood.

Clomid resistance is also known as clomiphene resistant or clomiphene citrate-resistant.

FertilitySmarts explains Clomid Resistant

Clomid is a drug that is used in the treatment of infertility due to abnormalities of ovulation. It acts by stimulating the hypothalamus to release more gonadotrophin-releasing hormone that in turn increases the release of other hormones in the hypothalamic–pituitary–gonadal axis such as luteinizing hormone ( LH), Follicle-stimulating hormone (FSH) and estrogen.

Clomid is usually started at a lower dose, and gradually increased depending on the response. A woman may be Clomid resistant simply because the dose is not adequate.

Some of the other conditions that can lead to Clomid resistance are:

  • Polycystic ovary syndrome (PCOS)
  • Obesity
  • Hyperprolactinemia (increased prolactin in the blood)

Obesity and hyperprolactinemia are correctable causes of Clomid resistance. Patients typically show an improved response to treatment with Clomid after weight loss or normalization of prolactin levels in the blood. For women who are Clomid resistant due to having PCOS, combining Clomid with metformin, DHEA or N-acetyl cysteine (NAC) has shown to be effective.

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