Estradiol Test

Definition - What does Estradiol Test mean?

An estradiol test is a test that measures the amount of a hormone called estradiol in the blood. Estradiol, also known as E2, is one of the predominant female hormones primarily produced by the ovaries, and in smaller amounts by organs above the kidneys called adrenals. In males, the testes and adrenals produce some amount of estradiol, but at a much lower rate than that in females. This hormone helps with the development of female sex organs including the uterus, fallopian tubes, vagina, and breasts. Estradiol also plays a role in bone health in females.

FertilitySmarts explains Estradiol Test

Measuring estradiol levels is most useful in the following situations:

  • Detecting developmental and puberty disorders in children: Higher estradiol levels for age indicate an earlier onset of puberty, known as precocious puberty whereas lower levels of estradiol may indicate late puberty
  • Assessing reproductive function in women: lower results before menopause mean premature ovarian failure or early menopause
  • Evaluating infertility
  • Monitoring ovulation after inducing it and planning further steps in IVF
  • Testing for feminizing disorders in men
  • Estimating the fracture risk in menopausal women
  • Evaluating for tumors in both sexes that produce estrogen

Before menopause, estradiol levels fluctuate widely throughout the menstrual cycle. However, the normal ranges of estradiol in picograms per milliliter (pg/ml) are:

  • Mid-follicular phase: 27-123 pg/mL
  • Close to ovulation: 96-436 pg/mL
  • Mid-luteal phase: 49-294 pg/mL

Following menopause: Under 10 pg/mL

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