Complex Abnormal Embryo (CA Embryo)

Definition - What does Complex Abnormal Embryo (CA Embryo) mean?

A complex abnormal embryo (CA embryo) refers to an embryo that has a chromosomal abnormality involving three or more chromosomes.

Chromosomal abnormalities of this nature could lead to spontaneous abortions or the development of an abnormal embryo. They are associated with low success rates in assisted reproductive technology (ART) treatments.

Complex abnormal embryos are sometimes called chaotic embryos.

FertilitySmarts explains Complex Abnormal Embryo (CA Embryo)

Aneuploidy, or having an abnormal number of chromosomes, can include endless numerical alterations in chromosomes, but aneuploidy of >2 would mean three or more abnormal chromosomes in cells of the embryo. This differentiation separates complex abnormal embryos from trisomy (n+1) and monosomy (n-1), which are comparatively more researched forms of aneuploidy.

Studies suggest that although the incidence of aneuploidy for one or two chromosomes increases with advanced maternal age, complex abnormal embryos are independent of the mother’s age. CA embryos tend to increase with repeated implantation failures.

Complex abnormal embryos are thought to be the result of errors in oocyte (immature egg cell) maturation and errors in embryo cleavage.

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