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Motile Sperm Organelle Morphology Examination (MSOME)

Definition - What does Motile Sperm Organelle Morphology Examination (MSOME) mean?

Motile sperm organelle morphology examination (MSOME) is a method of evaluating the sperm morphology with the help of an inverted light microscope. Some research shows that sperm selected through MSOME have improved fertilization rate, embryo quality, and implantation and pregnancy rates, while the rate of miscarriages also reduces significantly.

FertilitySmarts explains Motile Sperm Organelle Morphology Examination (MSOME)

Sperm abnormalities that are not visible at low magnification can easily be visualized through MSOME. It provides a real-time sperm assessment at ≥6300× magnification. MSOME assesses a sperm for abnormalities in six sperm organelles:

  • Acrosome (a cap-like structure in the anterior half of head of the sperm cells)
  • Post-acrosomal lamina
  • Neck
  • Tail
  • Mitochondria
  • Nucleus

A normal appearance of these organelles is indicative of a sperm's fertile potential. MSOME is indicated for couples who have had multiple failed assisted reproduction cycles.

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