Estrone (E1)

Definition - What does Estrone (E1) mean?

Estrone is a type of estrogen, the primary female sex hormone. Estrone is produced by women who have gone through menopause and no longer fertile.

The presence of estrone prior to menopause may indicate the presence of certain fertility comprising health conditions, including polycystic ovary syndrome (PCOS) or cancer.

FertilitySmarts explains Estrone (E1)

Estrogen is the primary female sex hormone. It regulates puberty, the menstrual cycle, and facilitates ovulation and pregnancy.

There are three types of estrogen produced by a woman’s body at different stages in her lifetime:

  • Estradiol is most common for non-pregnant women who are still fertile. Estradiol levels increase and decrease in accordance with the menstrual cycle. After menopause, a very small amount of estradiol remains in the body.
  • Estriol is produced during pregnancy. Secreted by the placenta, estriol production begins around the 9th week of gestation.
  • Estrone is produced after menopause. However, it can also be found in larger quantities in men or women who have certain types of cancer, including adrenal, testicular, or ovarian.

Additionally, abnormally heightened estrone levels may be present in people with certain health conditions, including polycystic ovarian syndrome (PCOS). PCOS causes the hormone estradiol to be inappropriately converted to estrone.

This increase of estrone blocks the production of an important sex hormone, follicle-stimulating hormone (FSH). FSH is responsible for follicle development, in the early stages of ovulation. Blocking FSH stops ovulation from occurring, causing female-factor infertility.

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