Luteinized Unruptured Follicle Syndrome (LUFS)

Definition - What does Luteinized Unruptured Follicle Syndrome (LUFS) mean?

Luteinized unruptured follicle syndrome (LUFS) describes a condition in which the egg matures inside the ovary but is never released. In the ovary, the follicle should burst open to release the egg once it is mature, allowing the egg to travel down the fallopian tube to the uterus. If this doesn’t occur, the egg remains trapped in the ovary. As a result, sperm can’t reach the egg to fertilize it.

FertilitySmarts explains Luteinized Unruptured Follicle Syndrome (LUFS)

After the release of the egg during normal ovulation, the cells of the ruptured follicle form a corpus luteum that secretes hormones. In LUFS, the unruptured follicle is “luteinized,” that is, it forms a corpus luteum just as though the follicle had burst to release the egg. This makes LUFS difficult to detect, because the woman’s menstrual cycle occurs normally with all the expected hormonal changes. Normal indicators of fertility occur, including changes in cervical mucus and a spike in basal body temperature that is usually an indication of ovulation.

LUFS can be diagnosed with an ultrasound examination of the ovaries, and may be treated with human chorionic gonadotrophin (hCG), possibly in combination with human menopausal gonadotrophin (hMG), to cause the release of the egg. LUFS may occur intermittently with normal ovulation.

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