Definition - What does Crinone mean?

Crinone is a medication with the active ingredient progesterone, a naturally occurring hormone that is essential for fertility. Progesterone has effects on various systems of the body including preparing the uterine lining for the fertilized egg and maintaining a pregnancy. Progesterone supplementation is used as a part of a fertility regimen in women who have natural progesterone levels that are too low.

During an in vitro fertilization (IVF) cycle some of the other medications such as gonadotropin-releasing hormone (GnRH) antagonists (Ganrelix, Cetrolide) and GnRH agonists (Lupron) that are given to prevent ovulation from occurring too early may alter progesterone levels. This may also be why progesterone is given to supplement fertility regimens.

FertilitySmarts explains Crinone

Crinone is given daily as a pill by mouth, intramuscular injection (IM), or as a vaginal suppository (sometimes twice or three times daily). The treatment is started three to four days after ovulation or on the day eggs are retrieved during IVF. Treatment is continued for two weeks. If the woman conceives during treatment, progesterone is usually continued until the embryo is at ten to twelve weeks. This is because low progesterone levels may cause early pregnancy loss. After ten weeks gestation, the placenta produces its own progesterone.

Oral progesterone has been shown to be less effective in contributing to a successful pregnancy. Intramuscular injection and vaginal suppository methods appear to be equally effective and are the preferred routes of administration. Women should avoid using tampons when using vaginal suppositories.

Common side effects of progesterone include constipation, abdominal pain, headache, mood swings, and painful or swollen breasts. Serious but rare effects of using progesterone hormone therapy include heart attack, stroke, or blood clotting. These serious effects are unusual in young healthy women. Women who smoke, have a history of blood clots, or are advanced in age may have an increased risk of these serious side effects.

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