Gamete Intrafallopian Transfer (GIFT)

Definition - What does Gamete Intrafallopian Transfer (GIFT) mean?

Gamete intrafallopian transfer (GIFT) is an assisted reproductive technology (ART) technique where female eggs are removed from the ovaries and inserted, along with sperm, into the woman’s fallopian tubes.

This type of treatment addresses fertility conditions that prevent the egg and sperm from self-navigating to the fallopian tubes, the site of fertilization and early cell division.

FertilitySmarts explains Gamete Intrafallopian Transfer (GIFT)

The first stage of GIFT is ovulation induction (OI). OI medication is used to stimulate the ovaries into producing multiple eggs per single ovulation cycle. Once the eggs have matured, they are gathered during an egg retrieval procedure.

Simultaneously, a semen sample is collected through masturbation, donor, or sperm retrieval. The semen undergoes a process called sperm washing, in which the ejaculate fluids, dead sperm, or other tissues are washed away from the healthy, living sperm.

The sperm and egg are kept separate until they are inserted directly into the woman’s fallopian tube, immediately following the retrieval and sperm washing. The procedure is completed while a woman is under general anesthesia, through a technique called a laparoscopy. A laparoscopy involves making a minor incision in the abdomen. A small tube called a catheter is used to transfer the sperm and egg to the appropriate area for transplant. If fertilization occurs, it happens in the following 24 hours.

GIFT is an appropriate procedure in the following circumstances:
  • The woman has at least one healthy fallopian tube
  • The man has low sperm count or sperm with motility concerns
  • Following IVF failure
  • Reluctance to use IVF
  • Unexplained infertility

However, research suggests that zygote intrafallopian transfer (procedure that involves lab based fertilization) may yield higher rates of conception success.

Share this: