Buserelin

Definition - What does Buserelin mean?

Buserelin is a synthetic form of gonadotropin-releasing hormone (GnRH) agonist. It is used to treat conditions including endometriosis and infertility. Buserelin binds to where GnRH normally signals and attaches to in the pituitary gland (the master hormone gland of the body). A single dose of buserelin mimics GnRH and causes the release of gonadotropins called luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, multiple doses of buserelin cause something called desensitization or down-regulation which is its desired effect. This inhibits the release of FSH and LH.

Buserelin is also known by the brand names Suprecur or Suprefact. It is similar to other GnRH agonists such as Lupron or Synarel. Buserelin may not be commercially available in some countries.

FertilitySmarts explains Buserelin

During in vitro fertilization (IVF), the suppression of LH and FSH prevents ovulation from occurring too early in the cycle. This allows for other fertility drugs to be used to cause ovulation at the right time. This allows for egg retrieval during a controlled cycle.

In cases of endometriosis, the suppression of LH and FSH reduces the proliferation of uterine tissue growth. This helps to reduce the uterine tissue that grows outside the uterus, causing painful side effects.

Buserelin is sometimes used to aid in fertility or treat symptoms in women with polycystic ovarian syndrome (PCOS).

Buserelin is usually administered once daily subcutaneously (below the skin) or three times daily via intranasal spray. There are different lengths of treatment that are used during IVF therapy usually started prior to initiation with human menopausal gonadotrophin (hMG). When used for endometriosis, the nasal spray is used three times daily up to six months.

Side effects of buserelin may include menopausal symptoms such as hot flashes, sweating, and vaginal dryness. Other side effects include headache, dizziness, gastrointestinal upset, acne, and vaginal bleeding. In patients with high blood pressure, depression, or diabetes this medication may worsen these diseases.

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