Fibrinogen

Definition - What does Fibrinogen mean?

Fibrinogen is a protein in the blood that promotes clotting. During pregnancy, the body increases fibrinogen production to naturally assist a mother during childbirth. However, too much fibrinogen can be dangerous, leading to a condition called hypercoagulability that can complicate or endanger pregnancy.

FertilitySmarts explains Fibrinogen

During pregnancy, the body’s levels of fibrinogen rise naturally. This rise, called hypercoagulability, increases the blood's ability to clot.

Researchers consider this an evolutionary tactic intended to prevent excessive bleeding during childbirth. However, this clotting may also have a negative impact on the body, increasing the woman’s risk of clotting disorders or complications.

In some situations, hypercoagulability can cause:

  • Miscarriage
  • Recurrent implantation failure
  • Implantation failure after IVF
  • Recurrent pregnancy loss (RPL)
  • Unexplained infertility
  • Low fetal birth weight
  • Placental abruption
  • Stillbirth
  • Deep vein thrombosis
  • Pulmonary embolism

Women who present with the preceding symptoms or complications may undergo a blood test to measure levels of fibrinogen in the blood. The presence of abnormally high levels of the protein may indicate increased fibrinogen levels as the cause of these complications.

Standard treatment for pregnant women with clotting disorders includes administering blood thinner medication, called anti-coagulant therapy.

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