All Q&A TreatmentIn Vitro Fertilization (IVF) Question Are frozen embryo transfer (FET) success rates higher than fresh transfers? Answer By Dr. Mark Trolice | Last updated: January 17, 2018 It is quite common for patients to ask if a frozen embryo transfer (FET) is likely to be more successful than a fresh embryo transfer. In medical literature, studies have shown that frozen embryo transfers (FET) were giving higher pregnancy rates. But after that data was stratified and analyzed further, it seems as though there's a select patient population that will benefit from FET. One group are hyper-responders (or high responders). These are patients on medication who produce lots of follicles that are going to produce a lot of eggs. All of those follicles make a lot of estrogen and the high levels of estrogen seem to have a little bit of a negative impact on embryo implantation at the lining of the uterus or the endometrium, resulting in lower pregnancy rates. For women who are hyper-responders, a freeze-all cycle is recommended for two reasons: To improve the implantation rate To reduce the risk of ovarian hyperstimulation syndrome (OHSS), a rare condition where you actually can get sick from having so many cysts on the ovaries developing and hospitalization is sometimes required. Other situations where patients are likely to benefit from FET: Patients who develop fluid in the lining of the uterus. This can happen from blocked swollen tubes, from polycystic ovarian syndrome (PCOS), a prior cesarean section called an isthmocele, where fluid can seep up into the endometrium and will reduce implantation. Patients with rising progesterone levels as this can have an effect on the lining of the uterus. Patients with multiple unsuccessful fresh transfers. So what's the bottom line here? Is frozen for all? Absolutely not—only a select patient population will benefit from frozen. Fresh is still an excellent opportunity that also reduces the cost of having to have another frozen cycle. Fresh and frozen are essentially equivalent, but in certain circumstances for select patients, frozen will be better. Who is that for? Hyper-responders, patients who have fluid in the lining, patients with elevated progesterone, patients where there is a concern about hyperstimulation or patients with multiple unsuccessful fresh transfers. Share this> Tags Embryo Development Treatment In Vitro Fertilization (IVF) Written by Dr. Mark Trolice | Infertility Specialist & Author Dr. Mark Trolice is double board certified in Reproductive Endocrinology & Infertility (REI) as well as OB/GYN. He maintains annual recertification in these specialties and has been awarded the prestigious American Medical Association’s “Physicians’ Recognition Award” annually for many years now. He is the director of Fertility CARE: The IVF Center in Orlando, FL, as well as Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Florida in Gainesville and the University of Central Florida in Orlando where he is involved in the teaching of OB/GYN residents and medical students. He is also the Lead Surgeon and Egg Donor Bank Medical Director for Cryos International. He is the voice behind The Fertility Health Podcast and the author of The Fertility Doctor's Guide to Overcoming Infertility. Read Dr. Mark Trolice's bio Follow: More Q&As from our experts Can I exercise after my IVF embryo transfer? Why did my in vitro fertilization (IVF) cycle fail? Can supplements improve egg quality for IVF? Related Terms Freeze All Cycle Frozen Embryo Transfer Day 3 Embryo Transfer Test-Tube Baby Congenital Bilateral Absence of Vas Deferens Days Post 3-Day Transfer Days Post 5-Day Transfer Days Past Ovulation Days Post-Retrieval Days Post-Transfer Related Articles Treatment Understanding IVF Extras: Intracytoplasmic Sperm Injection (ICSI) Treatment What You Should Know About Your IVF Lab Treatment 5 Things Your Embryologist Wants You To Know About Your IVF Procedure Health 10 Things You Should Know About Exercise During IVF Term of the Day Vitrification Vitrification is the technology created to rapidly freeze embryos, sperm, or eggs so that they can be preserved for later… Read Full Term Stay In The Know Sign up now for your monthly dose of fertility info, experiences, and insight. Email Address CommentsThis field is for validation purposes and should be left unchanged.